![]() ![]() Chiral recognition in dimerization of adsorbed cysteine observed by scanning tunnelling microscopy. The Lovász θ function, SVMs and finding large dense subgraphs. Jethava, V., Martinsson, A., Bhattacharyya, C. Geometrical and statistical properties of systems of linear inequalities with applications in pattern recognition. Electronic signature of DNA nucleotides via transverse transport. Identification of single nucleotide via tunnelling current. Long lifetime of hydrogen-bonded DNA basepairs by force spectroscopy. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Mass spectrometry evaluation of the solution and gas-phase binding properties of noncovalent protein complexes. Quantitative determination of noncovalent binding interactions using soft ionization mass spectrometry. Synthesis, physicochemical properties, and hydrogen bonding of 4(5)-substituted-1H-imidazole-2-carboxamide, a potential universal reader for DNA sequencing by recognition tunneling. Insulated gold scanning tunneling microscopy probes for recognition tunneling in an aqueous environment. Palladium electrodes for molecular tunnel junctions. LIBSVM: a library for support vector machines. Chemical recognition and binding kinetics in a functionalized tunnel junction. ![]() Interpreting the widespread nonlinear force spectra of intermolecular bonds. Recognition tunneling measurement of the conductance of DNA bases embedded in self-assembled monolayers. Electronic signature of all four DNA nucleosides in a tunneling gap. Identifying single bases in a DNA oligomer with electron tunneling. AFM fishing nanotechnology is the way to reverse the Avogadro number in proteomics. Reaping the Benefits of Genomic and Proteomic Research: Intellectual Property Rights, Innovation, and Public Health (National Academies Press, 2006).Īrchakov, A. National Research Council (US) Committee on Intellectual Property Rights in Genomic and Protein Research and Innovation. Antibody-based proteomics for human tissue profiling. The results suggest that direct electronic sequencing of single proteins could be possible by sequentially measuring the products of processive exopeptidase digestion, or by using a molecular motor to pull proteins through a tunnel junction integrated with a nanopore. With this recognition tunnelling technique, we are able to identify D and L enantiomers, a methylated amino acid, isobaric isomers and short peptides. A given molecule can bind in more than one way in the junction, and we therefore use a machine-learning algorithm to distinguish between the sets of electronic ‘fingerprints’ associated with each binding motif. Here, we show that single amino acids can be identified by trapping the molecules between two electrodes that are coated with a layer of recognition molecules, then measuring the electron tunnelling current across the junction. Therefore, the development of single-molecule protein sequencing is a critical step in the search for protein biomarkers. For DNA and RNA, low concentrations can be amplified using the polymerase chain reaction, but there is no such reaction for proteins. ![]() The human proteome has millions of protein variants due to alternative RNA splicing and post-translational modifications, and variants that are related to diseases are frequently present in minute concentrations.
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